By the end of this chapter, you will:

• Review the two long-term condition, diabetes and ME/CFS, that are being diagnosed in increasing numbers of patients
• Show awareness of how two conditions can often cause distress with major reductions in quality of life and involve significant care commitments from informal, family caregivers
• Review each condition in turn, including the causes, risk factors, the experience of living with the condition, interventions to ameliorate the symptoms and informal carers’ experiences
• Critique a major trial of psychotherapies applied to ME/CFS called the PACE trial